|
KMID : 1138520220250010046
|
|
Journal of Pharmacopuncture
2022 Volume.25 No. 1 p.46 ~ p.51
|
|
|
A Study on the Skin Irritation Toxicity Test of Processed Sulfur in New Zealand White Rabbit
|
|
Jung Ho-Seok
Seo Wook-Cheol
Jeong Tae-Seong
Kang Hyung-Won
Kim Sung-Chul
|
|
|
Abstract
|
|
|
Objectives: This study was performed to evaluate the skin irritation toxicity of processed sulfur.
Methods: All experiments were conducted at Medvill (Korea), an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate skin irritation toxicity of processed sulfur, we divided the back of six rabbits into two control sites and two test sites. One of each of the two control and test sites was then designated abraded sites and intact sites. In test sites, 0.5 g of processed sulfur was applied to the back of the rabbit for 24 hours, and in control sites, 0.5 g of sterile distilled water was applied in the same way. We observed and evaluated mortality, weight, general symptoms, and skin irritation toxicity. This study was conducted with the approval of the Animal Ethics Committee (Approval number: IAC2020-1549).
Results: In all experiments, no dead animals were observed. In all cases, skin coloration was observed at 24 hours after processed sulfur administration. This coloration lasted up to 48 hours and is believed to be the effect of the administration of test substances. Weight measurement indicated that weight was lost 72 hours after administration in three cases, but this is considered an accidental weight change. Normal weight gain was observed in the remaining subjects. In all animals, no skin irritation toxicity was observed, and the primary irritation index (P.I.I) was calculated as 0.0 according to Draize’s evaluation method.
Conclusion: The above findings suggest that it is relatively safe to apply a processed sulfur to the skin. Further research on this topic is needed to provide more specific evidence.
|
|
|
KEYWORD
|
|
|
herbal medicine, skin irritation toxicity, processed sulfur, toxicity test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|